A forty nine year old driver is in a critical condition after colliding with the central reservation just past junction 13 on the clockwise carriageway of the M60.
Police believe that he suffered a medical condition prior to the crash.
No arrests have been made and enquiries are ongoing.
Police Constable Adam Scott, of GMP’s Serious Collision Investigation Unit, said: “This tragic accident has left a man in a critical condition, and our thoughts remain with his family and friends at this very difficult time.
“Our enquiries are still in their early stages but due to the location of this incident we are hopeful that there are a number of witnesses who may have dash cam footage or information that could assist us.
“If this is you or you were on either side of the carriageway at around 8pm last night, please do not hesitate to get in touch with police.”