Yafiet Tesfalem, 17, was last seen about 7.40am on Thursday 21 March at YMCA hostel on Potato Wharf in Manchester City Centre.
Yafiet is described as black, 5ft 6ins tall and with short black afro hair. He was last seen wearing grey jogging bottoms and grey tracksuit top..
Officers are becoming increasingly concerned for Yafiet and want to make sure they are safe and well.
Anyone with information about Yafiet’s whereabouts is asked to contact police on 0161 856 4409.