A 28-year-old woman died in hospital in the early hours of this morning after the car she was driving a silver VW Polo was involved in a head on smash on the A555, Woodford Road in Stockport.
The Polo hit a silver Skoda around 2.30 this morning.
The 41-year-old man who was driving the Skoda remains in hospital with serious injuries.
The A555 was closed for a number of hours for accident investigation work and since re-opened in the early hours of this morning.
No arrests have been made and enquiries are ongoing.
Police Constable Suzanne Keenan of the Serious Collision Investigation Unit said: “This tragic incident sadly cost the life of a young woman and has left a man with serious injuries. Our thoughts are with both of their families during this devastating time.
“Our officers are working strenuously to find out what led to this collision and are asking anyone with dash cam or CCTV footage of the collision and anyone who may have seen the VW Polo in the moments prior to the incident to contact police as soon as possible.
“If you were on Woodford Road and saw the collision or were there in the moments after the incident please do not hesitate to speak with our officers.”