Firefighters are tackling the last few pockets of fire this morning at the Cube student apartment block in Bolton on Bradshawgate close to the town centre.
The fire,at the six storey building broke out around 8.30 yesterday evening.
Residents had already started to evacuate the building as firefighters arrived.
In total two people were treated by paramedics at the scene, including one person who was rescued by crews using an aerial platform.
At its height, around 200 firefighters were tackling the blaze, with 40 fire engines, three aerial platforms and other specialist appliances in use.
Road closures remain in place and people are urged to stay away from the area.
Assistant Chief Fire Officer Tony Hunter, said: “Our crews have done a fantastic job bringing this fire under control, in what have been very challenging circumstances. I want to praise their swift action, which has prevented the fire from spreading to adjacent buildings.
“I’m pleased the say that we are now scaling back our response, and we will remain at the scene for the next few hours as we tackle the remaining pockets of fire.
“Our priority now, is ensuring that all residents of The Cube register at Orlando Village on Thynne Street, Bolton so we know they are safe and well.”
The University of Bolton is supporting students who have been evacuated. They are urged to go to Orlando Village student accommodation, Thynne Street, BL3 6BA.
Professor George E Holmes DL, President and Vice Chancellor of the University of Bolton, said: “Supporting the welfare of our students is our number one priority and we have moved swiftly to assist in any way we can.
“University colleagues have worked through the night to make sure support is in place for students over the weekend.
“We have assisted in ensuring students have been given temporary alternative accommodation at the Orlando student halls and in some Bolton hotels.
“We have also arranged to provide necessities such as toiletries for all students affected and are opening the University over the weekend so students can be supported. We will also provide food for them.
“I would like to stress that The Cube is not owned by the University of Bolton. It is owned and managed by a private landlord and the students were not on our premises when during this incident.”